- 30 vegetarian capsules
- Vascular protection
- Blood Pressure
Gotu kola & Pycnogenol® help stabilize plaque in the arteries
Lipids and other waste can accumulate in blood vessels, forming plaque in the arteries. This plaque must remain stable in order to support optimal cardiovascular health and function. By encouraging the health of the thin cell layer that lines arteries, the endothelium, Arterial Protect encourages plaque stability,inhibits inflammation and oxidative stress to support arterial health.
Studies show that the extracts in Arterial Protect can help maintain the health, structure and function of the arterial lining.
Arterial Protect Benefits
- Helps stabilize plaque & promote healthy arterial blood flow
- Inhibits oxidative stress & inflammation to support vascular health
- Promotes vascular & endothelial health
Clinically studied Gotu Kola and Pycnogenol® French maritime pine bark extracts encourage the body’s natural processes for regulating plaque in the arteries and promote healthy arterial circulation.
Gluten free
Non-GMO
Vegetarian
Pycnogenol® and Centellicum® are registered trademarks of Horphag Research and the use of this product is protected by international patents.
Dosage and Use
Take one (1) capsule daily, or as recommended by a healthcare practitioner.
For more info:
Impede Arterial Plaque Accumulation
Two plant extracts can reduce arterial plaque progression by 95% while promoting plaque stability to lessen the risk of acute arterial occlusion.
By Michael Downey, Health & Wellness Author.
Atherosclerosis remains the Achilles tendon of aging humans.
A key characteristic is accumulation of
plaque inside
coronary, carotid, and other
arteries.1,2
The risk of a cardiovascular event is highest for those with the most advanced
arterial plaques. There are often no symptoms until this process triggers a
stroke or
heart attack.3
A standardized extract derived from
French maritime pine bark has been shown to halt plaque accumulation.
Supporting this, the plant extract
Centella asiatica has been shown to help preserve the hard cap on existing atherosclerotic plaques, making them less likely to
rupture and cause a fatal cardiovascular event.
Compelling studies reveal that when these plant extracts are combined, they provide more powerful benefits—for instance, reducing
plaque progression by a compelling
95%!4
Let's examine how these natural compounds work.
What you need to know
- The risk of a lethal cardiovascular event is highest for those with the most advanced arterial plaque—usually causing no symptoms until this process triggers a stroke or heart attack.
- Two compounds, standardized extracts of French maritime pine bark and Centella asiatica, have been documented to safely target this lethal process.
- Studies show that—taken together—they slow and even reverse plaque accumulation, while also boosting the stability of deadly soft plaque to help prevent a plaque rupture.
French Maritime Pine Bark Extract Blocks Plaque
French maritime pine extract contains a complex mixture of compounds known as
procyanidins and
phenolic acids5,6 that help slow the progression of
arterial plaque.4 How does it achieve this?
This pine bark extract alters fat metabolism and various cell-signaling factors (inflammatory cytokines) that contribute to plaque formation and progression.7,8
French maritime pine bark reduces a major inflammation-signaling molecular complex (
nuclear factor kappaB), resulting in lower levels of inflammation.7,8 This is critical, because chronic inflammation is a major factor in the development of atherosclerosis.
Animal studies have documented that French maritime pine bark reduces areas of plaque and lipid deposition in mice with atherosclerosis. This is accompanied by reductions in total cholesterol and triglyceride levels and increases in protective high-density lipoprotein (HDL) cholesterol.8
Another way that French maritime pine bark reduces the progression of atherosclerotic plaque is by
improving endothelial function.9,10 Evidence shows that it accomplishes this by stimulating a vital enzyme that produces
nitric oxide. Nitric oxide is a signaling molecule that endothelial cells use to communicate with the smooth muscle cells in arterial walls—helping them to relax and open up arteries.11
Scientists demonstrated this ability in lab experiments in which they constricted tissue from the aorta, the main blood vessel leading from the heart. They did this by using norepinephrine and epinephrine which is normally released in response to stress. This mimicked what happens in human arteries when blood flow is reduced.11
When the aorta was pretreated with French maritime pine bark, this blood-vessel constriction was
prevented due to increased synthesis of nitric oxide, which signaled arterial wall cells to relax. This process produced a wider artery and increased blood flow. Additionally, researchers found that increasing nitric oxide levels decreased platelet aggregation and the tendency to stick to vessel walls—which reduces the risks of blood clots and enlarging plaques.11
To validate these powerful and complementary actions, scientists conducted controlled clinical trials on human volunteers.
French Maritime Pine Bark Documented in Controlled Clinical Studies
When plaque and inflammation narrow the coronary arteries—which supply the heart with blood, oxygen, and nutrients, the result is coronary artery disease. To show how French maritime pine bark improves blood flow and endothelial function in patients with this condition, researchers conducted a randomized, placebo-controlled, crossover study on 23 patients with
coronary artery disease.12
Patients received either placebo or
200 mg of French maritime pine bark daily for eight weeks. Then, after a two-week "washout" period, each patient received the opposite treatment for another eight weeks.
By using a measure of how much the brachial artery (the main artery to the forearm) dilated in response to changes in blood flow (flow-mediated dilation), researchers were able to assess
endothelial function at the start of the study and after each treatment period.12
French Naritime Pine
While placebo treatment produced no significant changes, the pine bark extract treatment was shown to produce a significant
32% increase in
endothelial function and in
flow-mediated dilation.
Pine bark extract also reduced levels of compounds known as
isoprostanes—an index of how much
oxidized fat is present and a measure of overall oxidant stress while
placebo treatment produced no change. These findings demonstrated the pronounced ability of this pine bark extract to slow the fundamental, early arterial changes that lead to plaque formation and progression.12
Next, scientists in Italy designed a study to test the effects of this pine bark extract on individuals who had no obvious atherosclerotic changes in their blood vessels and who had not yet developed any clinically relevant coronary artery disease. They limited the experiment to volunteers who had definitive risk factors, including borderline levels of high blood pressure, blood lipids, and blood sugar—like most aging people. And like most people, these study subjects were in an ideal position for early, preventive intervention.13
Of the 93 volunteers, 32 had elevated blood pressure, 31 had high blood lipids, and 30 had elevated blood sugar. All participants continued their medical management of symptoms, but half of the subjects also took
150 mg of French maritime pine bark extract per day. Measurements of flow-mediated dilation were taken at the outset of the study, at eight weeks, and again at 12 weeks.13
The researchers found an increase in flow-mediated dilation of
55% in the supplemented group after eight weeks and an increase of
66% after 12 weeks. Also, measuring blood flow by a different method—laser Doppler flux—the team demonstrated similar increases at 8 and 12 weeks. Control participants, however, showed no significant changes in blood flow.13
Keep in mind that these study participants reflected the same borderline status that applies to most people—no symptoms, but a growing risk for the endothelial dysfunction that leads to plaque formation, progression, and ultimately, a serious cardiovascular event. Stressing this point, the study author wrote that French maritime pine represents, “
…an important preventive possibility for borderline hypertensive, hyperglycemic, and hyperlipidemic subjects.”13
Now, let's look at how this natural plaque-preventing pine bark extract can be complemented by another
plant extract that reduces the instability—and thus, the lethal risk of pre-existing plaque.
Centella asiatica Demonstrated to Stabilize Existing Plaques
Gotu Kola Centella asiatica
Early on in the process, arterial
plaques are
soft on the inside but covered with a hard, thick,
fibrous cap on the plaque surface that faces the blood flow.
As long as these plaques remain
thick, they are
stable, meaning they're firm enough not to pose a major risk of rupturing.14,15
Over time, this cap begins thinning and weakening, making plaque rupture more likely. The result is a deadlier, more unstable, softer plaque that may lead to ischemic stroke or heart attack.
So as critical as it is to
prevent plaque buildup, scientists have also long sought a way to
stabilize soft plaques.
Gotu Kola Centella asiatica
Centella asiatica, also known as
gotu kola, is an Asian aquatic plant containing compounds (triterpenoids) that stabilize soft plaque by improving the synthesis of collagen.16-19 Collagen is a component of the thick caps that hold soft plaque in place.17,20
Furthermore, this plant extract helps inhibit progression of plaque by reducing the adhesion of immune system cells (monocytes) that promote atherosclerosis.21
Participants with soft plaque were given
60 mg of Centella asiatica extract three times daily. After 12 months, their carotid-artery plaque was denser (harder, safer) by an average of
30%.20
Then, in phase two, researchers used the same dose, but in a randomized, placebo-controlled trial.
The results showed that carotid-artery
plaque stability significantly improved. MRI scans demonstrated reduced blood flow to the brain in
17% of controls, but only in
7% of the
Centella asiatica group. And supplemented subjects experienced
41% fewer cardiovascular events.20
In a similar, placebo-controlled study of volunteers with soft (high-risk) plaque in their femoral artery (the major artery in the thigh), scientists found that
60 mg of
Centella asiatica extract three times daily produced a
63% harder plaque—indicating reduced rupture risk—in just 12 months. Critically, plaque size increased
23% in controls while Centella-supplemented patients showed
zero plaque-size increase.17
Scientists then decided to combine plaque-stabilizing
Centella asiatica with plaque progression-inhibiting
French maritime pine bark. Let's now examine some studies conducted with this
dual-compound formula.
Clinical Effects of Dual-Compound Supplement
To demonstrate the atherosclerosis-inhibiting effects of combining French maritime pine with Centella asiatica, scientists enlisted individuals aged 45 to 60 who had no cardiovascular risk factors or symptoms—but who did have plaques that did not narrow their arteries more than
50% (class IV).4
Several groups were assigned different supplements along with lifestyle, diet, education, and exercise recommendations. After 30 months, using ultrasound, researchers found that the percentage of
plaques that had worsened from class IV to V (blocking over
50% of an artery) was:4
21.3% in controls receiving only diet/lifestyle recommendations (worst-performing group),
16.6% with
100 mg aspirin (or ticlopidine, an antiplatelet drug, for aspirin-intolerant subjects),
8.4% with
50 mg standardized French maritime pine bark alone,
5.3% with
100 mg standardized French maritime pine
bark alone,
4.0% with
100 mg standardized French maritime pine bark plus
100 mg aspirin (or ticlopidine), and
1.1% with
100 mg standardized French maritime pine bark plus
100 mg extract of Centella asiatica (best-performing group).
So in volunteers taking both compounds,
plaque progression was an impressive
95% lower than in controls!4
Then, scientists assigned the same dosages to subjects with advanced atherosclerosis—meaning at least one class V arterial lesion. Class V involves an
instance of over-
50% blockage without symptoms, while class VI also involves symptoms such as numbness, tingling, pain, or other, more serious symptoms. After 42 months, the percentage with plaques that had progressed from class V to VI was:22
48% in controls (worst-performing group),
21% with taking aspirin or ticlopidine,
11% with
100 mg standardized French maritime pine bark plus aspirin,
10% with
100 mg standardized French maritime pine bark alone, and
6.5% with
100 mg standardized French maritime pine bark plus
100 mg extract of
Centella asiatica (best-performing group).
The combination of standardized extracts of
French maritime pine bark and Centella asiatica provided a
7.4-fold reduction in the risk of developing cardiovascular-disease symptoms compared to controls—and a nearly
four-fold reduced risk of being hospitalized for a full-blown cardiovascular event.22
Next, scientists conducted a study that demonstrated the effects of this dual-nutrient formula in
stabilizing soft arterial plaques—and in blocking the
progression of
plaque accumulation in aging arteries.23
They evaluated carotid plaque stability, before and after three months' supplementation, in 50 symptom-free volunteers with arterial plaque stenosis of less than
50% (class IV), high oxidative stress, and a mean age of 61.5 years. Daily for three months, half were given
150 mg of standardized extract of
French maritime pine bark along with
225 mg of an extract of
Centella asiatica. All patients also received standard management care.23
Compared to controls, supplemented patients significantly
improved on the
plaque stability index. The "white component" of their plaque substantially increased, based on ultrasound imaging, indicating improved plaque density and significant risk reduction. Also, plaques were decreased in length, height, and number. Free radicals in the supplemented group's plasma were significantly reduced. There were no adverse effects. By contrast, standard plaque management produced no significant improvements.23
Further Clinical Validation
Two recent studies further document the capacity of this dual-compound formula to both inhibit plaque progression and stabilize plaques.24,25
Scientists enlisted patients, aged 45 to 60, with at least one instance of atherosclerotic plaque of
50%-60% occlusion and divided them into three groups. All groups were managed with education, exercise, diet and lifestyle changes. One group also received
100 mg of standardized French maritime pine bark daily, while another group received
100 mg of the pine bark extract plus
100 mg daily of
Centella asiatica.23
After four years, there was a significant reduction in plaque progression rates for both treatment groups, but the combined formula provided the "best effects" in terms of plaque thickness and length.
Angina and oxidative stress were less for both treatment groups (pine bark alone or pine bark + Centella). But
heart attacks (myocardial infarctions) were fewer in the
dual-extract group. The study author wrote that both the pine bark extract alone and the combined formula
“reduce the progression of arterial plaques and the progression to clinical stages.”24
Then, a study team used a measure called
echogenicity to assess (carotid-femoral) plaques in 79 asymptomatic patients with atherosclerosis risk factors—either mildly high blood pressure or elevated cholesterol—all of whom were given standard control management. Only 36 of these patients received daily supplements of both French maritime pine and Centella asiatica.25
After six months, compared to controls, the supplemented participants were found to have greater plaque-stability scores, better plaque "white component" (more density), fewer plaques, decreased maximum plaque height, and decreased plasma free radicals—with no adverse events.25
Clearly, French maritime pine bark and Centella asiatica extracts—both individually and especially combined—reduce plaque progression and promote plaque stability.
Summary
The accumulation of
plaque inside the coronary and other arteries often occurs without symptoms up until a stroke or heart attack strikes.
Researchers have identified two natural compounds that safely target this lethal progression.
Together, they have been shown to slow and even reverse plaque accumulation, while boosting the stability of deadly soft plaque to help prevent a plaque rupture.
A combination of
French maritime pine bark and
Centella asiatica provides the backup that most adults need to support more comprehensive cardiovascular protection.
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.
References
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Leskinen MJ, Kovanen PT, Lindstedt KA. Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells--a potential mechanism for the weakening and rupture of atherosclerotic plaques. Biochem Pharmacol. 2003 Oct 15;66(8):1493-8.
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Incandela L, Belcaro G, Nicolaides AN, et al. Modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, randomized, placebo-controlled trial. Angiology. 2001 Oct;52 Suppl 2:S69-73.
Incandela L, Cesarone MR, Cacchio M, et al. Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. Angiology. 2001 Oct;52 Suppl 2:S9-13.
James JT, Dubery IA. Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. Molecules. 2009 Oct 9;14(10):3922-41.
Cesarone MR, Belcaro G, Nicolaides AN, et al. Increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled, randomized trial. Angiology.2001 Oct;52 Suppl 2: S19-25.
Ivanov V, Ivanova S, Kalinovsky T, et al. Plant-derived micronutrients suppress monocyte adhesion to cultured human aortic endothelial cell layer by modulating its extracellular matrix composition. J Cardiovasc Pharmacol. 2008 Jul;52(1):55-65.
Belcaro G, Ippolito E, Dugall M, et al. Pycnogenol(R) and Centella asiatica in the management of asymptomatic atherosclerosis progression. Int Angiol. 2015 Apr;34(2):150-7.
Luzzi R, Belcaro G, Ippolito E. Carotid plaque stabilization induced by the supplement association Pycnogenol(R) and centella asiatica (Centellicum(R)). Minerva Cardioangiol. 2016 Dec;64(6):603-9.
Belcaro G, Dugall M, Ippolito E, et al. Pycnogenol(R) and Centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. Minerva Cardioangiol. 2017 Feb;65(1):24-31.
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